Regulation of Enzymatic Activity

Insulin Glucagon/Epinephrine

Indicates high glucose levels Indicates low blood glucose/

Activates Protein Phosphotase need for blood glucose

Leads to dephosphorylation Activates cAMP

Protein kinase

Leads to phosphorylation

Enzyme Active Inactive

Glycogen Synthase -OH -P

Glycogen Phosphorylase -P -OH

PFK-2 (kinase) -OH -P

(phosphotase) -P -OH

Pyruvate Kinase -OH -P

Pyruvate dehydrogenase -OH -P

Lipase -P -OH

Acetyl CoA carboxylase -OH -P

HMG CoA reductase -OH -P